Navigating the Overdrive of Graves’ Disease

The racing heart, anxiety, and severe tiredness of Graves’ disease can disrupt your entire life. While daily medications help many manage symptoms, clinical … research is exploring new approaches to understanding and managing this condition.

See If You Qualify

WHO CAN PARTICIPATE?

Clinical studies have strict guidelines to ensure patient safety and accurate results. While every study is different, currently enrolling local studies are looking for individuals who:

Are 18 years old or older and living with Graves’ disease
Are currently taking a steady, daily dose of medications for their Graves’ disease
Have never had radioactive iodine therapy or surgery to remove their thyroid

Additional criteria apply. A study doctor will determine final eligibility based on full medical criteria.

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How Clinical
Trials Work

Clinical trials are the foundation of medical advancement. They are carefully monitored research studies designed to test new treatments to see if they are safe and effective. Participating in a clinical trial means not only exploring a new potential option, but also helping shape the future of Graves’ disease care for generations to come.

Here’s a look at what a clinical trial for Graves’ disease might involve:

A principal investigator, or PI, is the physician in charge at a designated study site for the clinical trial who is responsible for coordinating and overseeing the clinical study. That individual carries out what is called a protocol.

A Protocol is a document that describes how the trial is designed, and outlines how it should be carried out.

Clinical trials, also called research studies or clinical studies, can be either interventional, or non-interventional. Interventional studies mean that they test out an intervention, like a drug, procedure or medical device. Non-interventional studies, also called observational studies, don’t test potential treatments. Instead, researchers observe the participants over a period of time, and track health outcomes.

Clinical Trials Make a Difference

Participation in a clinical study provides valuable information that could eventually lead to a better treatment and — with the right advancements — to better outcomes. Take our short survey to see if you or a loved one may be a good fit. There is no obligation to enroll.

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Understanding Graves’ Disease

WHAT IS IT?

Graves’ disease is an autoimmune condition where the immune system mistakenly attacks the thyroid gland. This causes the gland to produce too much thyroid hormone, a state known as hyperthyroidism. This overproduction forces your body’s systems to speed up and can lead to symptoms like a rapid heartbeat, shaking hands, sleep problems, and severe tiredness.

HOW IS IT TREATED?

Current treatments try to control symptoms and bring thyroid hormone levels back to normal. While these treatments help, there is no cure, and they don’t work for everyone. Other options include radioactive iodine or surgery to remove the thyroid, both of which permanently change how the thyroid works. This is why research continues to look for new paths.¹

HOPE FOR THE FUTURE

Dealing with the physical toll of Graves’ disease can feel like a full-time job. By volunteering for clinical research, participants play a vital role in helping researchers understand how to better manage the condition in the future.

3,000,000+

Number of people currently living with Graves’ in the United States, about 1% of the U.S. population.²

1. Source: https://gdatf.org/fast-facts/graves-disease/

2. Source: https://www.yalemedicine.org/conditions/graves-disease

FREQUENTLY ASKED QUESTIONS

What is the purpose of these studies?

To evaluate the effectiveness and safety of new potential treatments for Graves’ disease.

What are the symptoms of Graves’ disease?

Signs may include:¹

Feeling nervous and irritable
Slight tremor of the hands or fingers
Heat sensitivity, with an increase in sweating or warm, moist skin
Weight loss, despite wanting to eat more
Having an enlarged thyroid gland
Changes in menstrual cycles
Having frequent bowel movements
Fatigue
Having fast or irregular heartbeat, called palpitations
Not sleeping well

1.Source: https://www.mayoclinic.org/diseases-conditions/graves-disease/symptoms-causes/syc-20356240

What will happen during a clinical study for Graves’ disease?

Most clinical trials will involve a screening visit to confirm that a potential participant is, in fact, a match for that trial’s criteria. Once verified, an Informed Consent Form, which clearly provides the details and purpose of the trial to that individual and what it involves, is reviewed, with the participant to sign.

Participants can then expect to attend scheduled appointments at a trial clinician’s site. They may also receive a trial treatment (also called an investigational product) or a control (also known as placebo, which contains no active treatment) and undergo additional assessments and follow-up monitoring.

Throughout the trial, participants should experience a professional clinical environment and be treated with compassion and respect.

Are there any costs to participate?

There is no cost to participate in a clinical trial. Participants receive all study-related medical care and medications for the duration of the study at no cost. Likewise in many instances, participants may also receive reimbursement for time and travel.

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